A NEW SERIES OF PYRROLE-BASED CHALCONES: SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY, CYTOTOXICITY, AND GENOTOXICITY

A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity

In an effort to develop English saddles new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with 5-(aryl)furfural derivatives.The compounds were evaluated for their in vitro antimicrobial effects on pathogenic bacter

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Bond behaviour evaluation between steel reinforcement and self-healing concrete containing non-axenic biomasses

Although steel reinforcements are used to withstand tensile forces in concrete, cracks are an unavoidable phenomenon.The presence of cracks, in fact, increases the risk for lowering the service life and durability of concrete structures.A critical issue occurs when due to splitting forces, cracks appear in concrete along the tensioned rebars which

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Process analytical technology as in-process control tool in semi-continuous manufacturing of PLGA/PEG-PLGA microspheres

Nowadays, among 3rd generation drug delivery systems, biodegradable polymeric based long-acting injectable depot has achieved tremendous success in clinical application.So far, there have been two dozen of commercial products of Poly (lactic-co-glycolic acid) microspheres available in the market.Recently, continuous manufacturing concept has been s

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